When client’s lives just keep getting worse

I have several clients who, despite all their best efforts, are dealing with setback after setback. I’m struggling with feelings of helplessness. I worked in hospice for many years before starting a private practice, so I’m very comfortable with the reality of pain and suffering. But that was all short term work. Now that I’m seeing people for long term work, I find myself feeling helpless. I know that being present, reflecting their strengths and progress, and helping them treat themselves more compassionately is all I can do. But I feel so bad for them- husbands die, jobs are lost, kids get sick- and I feel like I should be able to help more. I’m not sure what kind of advice I’m asking for, but I guess I just want to know what helps others cope.