What infection/precaution scares you the most as a nurse?

Obviously, any infection is a bad infection, but my coworkers and I (Adult MICU) were discussing our least favorite ones to deal with for our patients. Any airborne disease is never fun to work with (looking at you, TB rule out), but one of the more common ones lately that is our consensus least favorite is norovirus. The cleanups are all I have to say about that.