Spouse thinks I am a loser

I think I am in an unusual situation that may be specific to academia and the MD/PhD route. Essentially, my wife stated that she thinks that I am a loser for working so hard but earning so little. This interpretation struck me by surprise.

I have to admit that it was extremely hard to get to where I am because of the large amount of competition in academia. When everyone went home after clinical work, I had to continue research into the night after the PhD, then into residency and fellowship to make this research dream come true. The work ultimately paid off with an 80/20 assistant professor appointment. I competed against a very large number of other applicants, not including most of my peers who decided to leave the physician-scientist route because of the difficulty and large time commitment.

The pros of my current setup are that I am now in my dream job and work long hours without feeling like it is "work." I also feel proud of myself that I was able to grind through for so long, and that I have now made many incredible scientific discoveries that I would have only dreamed of as a child.

The cons are that I took about a 50% pay cut and am working long hours to continue research, maintain a lab and maintain grants. So, I again work a lot more than my clinical-only peers by a long shot. Now my wife recently stated, in a bout of pent-up frustration, that she thinks I am a loser because I work so much but earn so little. She is growing resentful of my work, believing that it takes time away from her. Note that this was a gradual process. She was initially supportive of my endeavors, but the long hours alone and low pay have eventually eaten at her over the years. I understand that even the best of intentions may not be enough, due to how difficult the physician-scientist route is.

Has anyone else gone through something similar and, if so, what did they do about it? We have tried therapy but this issue of overwork remains a fundamental problem. Are physician-scientists just doomed to this problem, or doomed to essentially date a very small group of people who are okay with being alone a lot?

Edit: I appreciate the thoughtful responses. To clarify, the 50% pay cut is in relation to private practice. I am making close to 100% of the clinician-educator salary at my institution. My wife is a hard worker and high earner. We started with very similar mindsets and thus got along well. Her path took time, but overall much less time and less effort (I hate to compare very different career paths, but I think this statement is fair). She is noticing that, despite putting in half the effort and time, she is earning close to what I am already and will likely surpass it in the near future. I think it is hard for her to understand the pay-to-work ratio, where physician-scientists must in general work much harder for the same amount of dollars relative to most other careers that I am aware of.