Places to "run away" to from Lexington

For the sake of brevity, I'll just say that I need a few days away from normalcy. I don't mind driving 2 or even 3 hours away, not much further though. Ideally, I'll end up somewhere in or close to nature. That, and/or a place with a few cool attractions. The less busy the better, so please not Gatlinburg lol. Where do you like to run off to? Or, where do you wish you had time to run off to?