Meemaw’s Bad Attitude

1. In the episode where Sheldon chokes and subsequently stops eating solid food, Connie makes the joke that ‘constipation won’t be one of Sheldon’s problems’.

Plus

1. During Mandy’s delivery, Meemaw is already at the hospital because of hemorrhoids.

Equals

I posit that Meemaw suffered from chronic constipation and this contributed towards her bitter and salty attitude.