Legendary xenos orbs who go spend on?

I have 30, and Snotflogga, Aethana, snd Eldyron able or close to be Able to be ascended am I good to pull the trigger on these 3?

I'm working on aleph null here soon I have to unlock epic for him still so he's a ways off here, but would these 3 be relatively safe to just ascend now?

I know Eldyron is but what about the other two I guess? I'm think the 20% buff is rather strong on them both and they're both capped at g1