Path to Tier 12 - Wave 4500

Currently working to get to Wave 4500 on tier 12. Trying to figure out the path forward and what I should focus on.

Is PS going to get me there? Is more SM damage the trick forward? Any other labs I should focus my attention on? What tips do you have for me?

I typically make about 550b coins in a farming run and get top 3 in champ. Tier 12 wave 4500 seems to be the next big road block for progression besides being bottle necked by stone progression.