Interested to see how PSSD sufferers are viewing their condition in light of the Melcangi research: neurotransmitters, PNMT (epinephrine), gut microbiota, inflammation

Hey everyone,

I’ve been reading the recent research by Melcangi, and I’m curious about how others are interpreting the findings in relation to their PSSD and recovery. The study discusses neurotransmitter changes, PNMT (which affects epinephrine production), gut microbiota shifts and inflammation. This is my understanding of the research not stating it to be fact: https://docs.google.com/document/d/1-L5ShVv8I9bIAMbOcW48Bzh6x5F6ZS_0q6_x9q1COUE/edit?usp=drivesdk

For me personally, I’ve had three brief windows of relief from taking L-Tyrosine (seems to impact dopamine and epinephrine when I take it), which is the only thing that has helped with genital numbness and anorgasmia. I know a guy with PSSD who has experiences relief with yohimbine which has an effect on epinephrine(is actually prescribed in France for erectile dysfunction under the brand name Vidal). Am interested to know also about extended fasting, as I have seen posts about that in the past and fasting is postulated to effect inflammation.

Looking forward to hearing your thoughts!