Planescape Integration Pointers Wanted

I’m working on a home brew 5e setting and campaign which will involve elements of planar travel as players have to fight their way across planes to stop the collapse of the planes themselves. I’m not opposed to using premade content to help flesh out the campaign so I’m not reinventing the wheel more than needed, so I was looking at incorporating Plane Scape into it with modifications made to fit my setting as needed.

I would appreciate any insights offered on integrating Plane Scape, or just my campaign in general. There are a lot of first times here for me: writing a story, writing a campaign, writing a setting, doing anything with PlaneScape, GMing an entire campaign.

I’m not looking for anyone telling me to lower my scope though. That attitude can go find a different post. I’m having fun and want to do this and so does my table.