Most effective and profoundly noticeable substance for Social Anxiety

I don‘t know if you suffer from social anxiety but everyone knows some moment in life where you are not feeling much social and can differentiate it from having big joy and drive in socializing, being talkative, open, extroverted, seeking conversation and chats and looking to have fun socializing and meet people.

Is there any substance (supplement, nootropic, whatever) that helped you getting effects like that? Which were the most effective ones that were definitely (more than subtle, just „maybe“ or placebo) noticeable, clearly psychoactive in that regard and showed profound effects in increasing sociability making you more social, talkative, extroverted and open to/for people, meeting new people and starting or participating in conversation?

Did this substance work instantly like right away after first time dosing or is it rather something that you need to build up by taking it regularly for some time until first effects occur (for example like SSRI antidepressants)?

Would love to hear about everyone‘s experiences!

Thank you guys for any suggestion!